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All evidence derives from animal models and in-vitro studies

The positive effects of cortisone treatment are manageable compared to the side effects

In normal conditions, Nrf2 remains inactive as it binds to cytoplasmic Kelch-like ECH-related protein 1 (Keap1)

This process is primarily driven by the RIPK1-RIPK3-MLKL signaling axis (Zhang X

Our previous study also identified a significant association between the NNMT genetic variant at rs1941404 and T2D in the Chinese Han population (Li et al., 2018)